The Torah in Parashat Emor (Vayikra 22:22) lists several physical blemishes that disqualify an animal as sacrifice, and then commands, “Lo Takribu Eleh L’Hashem” – that such animals may not be sacrificed to G-d.
The Gemara in Masechet Temura (6) interprets this verse as referring to specifically the sprinkling of the animal’s blood after slaughtering. Separate commands prohibit other stages of the sacrificial process, but this verse introduces a prohibition against sprinkling the blood of a blemished animal sacrifice on the altar. Therefore, if an animal was consecrated and had a blemish, and after it was slaughtered, somebody sprinkled its blood on the altar, he would be liable to Malkut for transgressing this command.
Of course, as the Sefer Ha’hinuch notes, this prohibition applies only in the time of the Bet Ha’mikdash, when sacrifices were offered.